MovDisordV3, Main, Exploration, bibRecord, 000687

A network approach to diagnostic biomarkers in progressive supranuclear palsy.

Identifieur interne : 000687 ( Main/Exploration ); précédent : 000686; suivant : 000688

A network approach to diagnostic biomarkers in progressive supranuclear palsy.

Auteurs : Jose A. Santiago [États-Unis] ; Judith A. Potashkin

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.

RBID : pubmed:24347522

English descriptors

KwdEn :
- Aged, Biological Markers, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Parkinson Disease (diagnosis), Parkinson Disease (metabolism), Prospective Studies, Supranuclear Palsy, Progressive (diagnosis), Supranuclear Palsy, Progressive (metabolism), Tissue Array Analysis.
MESH :
- chemical : Biological Markers.
- diagnosis : Parkinson Disease, Supranuclear Palsy, Progressive.
- metabolism : Parkinson Disease, Supranuclear Palsy, Progressive.
- Aged, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Prospective Studies, Tissue Array Analysis.

Abstract

Diagnosis of progressive supranuclear palsy (PSP) remains challenging because of the clinical overlap with Parkinson's disease (PD). To date, disease-specific biomarkers have yet to be identified. In the absence of reliable biomarkers, we used an integrated network approach to identify genes and related biological pathways associated with PSP. We tested a highly ranked gene in cellular whole-blood samples from 122 patients enrolled in the Prognostic Biomarker Study. Biological and functional analysis identified 13 modules related to activation of leukocytes and lymphocytes, protein dephosphorylation, and phosphatase activity. Integration of these results with those from microarrays identified ptpn1 as a potential biomarker for PSP. Assessment of biomarker performance revealed that ptpn1 could be used to distinguish PSP patients from PD patients with 86% diagnostic accuracy. Ptpn1 may be a diagnostic marker useful for distinguishing PSP and PD. Further evaluation in a larger well-characterized prospective study is warranted.

DOI: 10.1002/mds.25761
PubMed: 24347522

Affiliations:

Le document en format XML

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<author><name sortKey="Santiago, Jose A" sort="Santiago, Jose A" uniqKey="Santiago J" first="Jose A" last="Santiago">Jose A. Santiago</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Cellular and Molecular Pharmacology, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA.</nlm:affiliation>
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<wicri:regionArea>Department of Cellular and Molecular Pharmacology, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois</wicri:regionArea>
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<author><name sortKey="Potashkin, Judith A" sort="Potashkin, Judith A" uniqKey="Potashkin J" first="Judith A" last="Potashkin">Judith A. Potashkin</name>
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<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Prospective Studies</term>
<term>Supranuclear Palsy, Progressive (diagnosis)</term>
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<front><div type="abstract" xml:lang="en">Diagnosis of progressive supranuclear palsy (PSP) remains challenging because of the clinical overlap with Parkinson's disease (PD). To date, disease-specific biomarkers have yet to be identified. In the absence of reliable biomarkers, we used an integrated network approach to identify genes and related biological pathways associated with PSP. We tested a highly ranked gene in cellular whole-blood samples from 122 patients enrolled in the Prognostic Biomarker Study. Biological and functional analysis identified 13 modules related to activation of leukocytes and lymphocytes, protein dephosphorylation, and phosphatase activity. Integration of these results with those from microarrays identified ptpn1 as a potential biomarker for PSP. Assessment of biomarker performance revealed that ptpn1 could be used to distinguish PSP patients from PD patients with 86% diagnostic accuracy. Ptpn1 may be a diagnostic marker useful for distinguishing PSP and PD. Further evaluation in a larger well-characterized prospective study is warranted.</div>
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Movement Disorders (revue)

A network approach to diagnostic biomarkers in progressive supranuclear palsy.

A network approach to diagnostic biomarkers in progressive supranuclear palsy.

Source :

English descriptors

Abstract

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Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Movement Disorders (revue)
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